About the Lab

Location

The Pagliassotti lab is located at Colorado State University in Fort Collins, Colorado. Fort Collins is situated in Northern Colorado near the Colorado-Wyoming border, directly against the foothills of the Rocky Mountains. The city population is approximately 140,000, and the University studentship is approximately 25,000. Colorado State is home to approximately 1,400 faculty among 55 academic departments. For more information on Fort Collins or Colorado State University, please visit the following pages:

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Space & Equipment

Our laboratory space is located on the second floor of the Gifford building on the southern edge of the CSU main campus. The space includes separate laboratories for Molecular Biology-based analyses, protein and biochemistry-based analyses, cell biology-based studies, and in vivo studies. In addition, there are shared facilities for gas chromatography, liquid scintillation counting, high-speed centrifugation, tissue processing and sample storage. Office space for students and staff is also located on the second floor of the Gifford building.

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Lab Attitude

The lab has two mottos, the first says it all:

  • "If we knew what we were doing, it wouldn’t be called research” - Albert Einstein
  • “Give back more than you receive” - Unknown

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Lab Publications

Publications from the CSU-based lab:

  1. M.J. Pagliassotti, Y. Wei, M.E. Bizeau. Lack of suppression of glucose-6-phosphatase activity and increased mRNA following ingestion of a sucrose-enriched meal in rats. J. Nutrition 133:32-37, 2003.
  2. H. Yamashita, J. Shao, L Qiao, M. Pagliassotti, J.E. Friedman. Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Leprdb/+ mice. Pediatric Research 53:411-418, 2003.
  3. Y. Wei, M.E. Bizeau, M.J. Pagliassotti. An acute increase in fructose concentration increases glucose-6-phosphatase mRNA via mechanisms that are independent of glycogen synthase kinase-3 in rats. J. Nutrition 134:545-551, 2004.
  4. Y. Wei and M.J. Pagliassotti. Hepato-specific effects of fructose on c-jun N-terminal kinase: Implications for hepatic insulin resistance. Am. J. Physiol. 287:E926-E933, 2004.
  5. S. Cardin, M.J. Pagliassotti, M.C. Moore, D.S. Edgerton, M. Lautz, B. Farmer, D.W. Neal, A.D. Cherrington. Vagal cooling and concomitant norepinephrine infusion do not reduce net hepatic glucose uptake in the conscious dog. Am. J. Physiol. 287:R742-R748, 2004.
  6. M.J. Pagliassotti and T.J. Horton. Sucrose, insulin action and biologic complexity. In: Recent Research Developments in Physiology; S.G. Pandalai, editor. Research Signpost, 2:337-353, 2004.
  7. L. Puljak, M.J. Pagliassotti, Y. Wei, I. Qadri, V. Parameswara, V. Esser, G.J. Fitz, G. Kilic. Inhibition of cellular responses to insulin in the liver. A role for PKC in insulin resistance. J. Physiol. 563:471-482, 2005.
  8. J. Shao, L. Qiao, K. VanAuken, Y. Wei, M.J. Pagliassotti, J.E. Friedman. Sustained high glucose enhances phosphoenolpyruvate carboxykinase gene expression and hepatocellular glucose production via elevated LAP/LIP ratio. Diabetes 54:976-984, 2005.
  9. L. Qiao, P.S. Maclean, J. Schaack, D.J. Orlicky, C. Darimont, M. Pagliassotti, J.E. Friedman, J. Shao. C/EBPα regulates human adiponectin gene transcription through an intronic enhancer. Diabetes 54:1744-1754, 2005.
  10. M.E. Bizeau and M.J. Pagliassotti. Hepatic adaptations to sucrose and fructose. Metabolism: Clinical and Experimental 54:1189-1201, 2005.
  11. Y. Wei, D. Wang, M.J. Pagliassotti. Fructose selectively modulates c-jun N-terminal kinase and insulin signaling in primary rat hepatocytes. J. Nutrition 135:1642-1646, 2005. /
  12. D. Wang, Y. Wei, D. Schmoll, K.N. Maclean, M.J. Pagliassotti. Endoplasmic reticulum stress increases glucose-6-phosphatase and glucose cycling in liver cells. Endocrinology 147:350-358, 2006.
  13. D. Wang, Y. Wei, M.J. Pagliassotti. Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology 147:943-951, 2006.
  14. Y. Wei, D. Wang, F. Topczewski, M.J. Pagliassotti. Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am. J. Physiol. 291:E275-E281, 2006.
  15. Y. Wei, D. Wang, M.J. Pagliassotti. Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by Trans 10, Cis 12-conjugated linoleic acid in liver cells. Molecular and Cellular Biochemistry 303:105-113, 2007.
  16. M.J. Pagliassotti, Y. Wei, D. Wang. Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity. Endocrinology 148:3338-3345, 2007.
  17. Y. Wei, D. Wang, F. Topczewski, M.J. Pagliassotti. Fructose-mediated stress signaling in the liver: Implications for hepatic insulin resistance. J. Nutr. Biochem. 18:1-9, 2007.
  18. J.C. Gonzales, C.L. Gentile, K. Pfaffenbach, Y. Wei, D. Wang, M.J. Pagliassotti. Chemical induction of the unfolded protein response in the liver increases glucose production in vivo and is activated during insulin-induced hypoglycemia in rats. Diabetologia 51:1920-1929, 2008.
  19. C.L. Gentile and M.J. Pagliassotti. The role of fatty acids in the development and progression of non-alcoholic fatty liver disease. J. Nutr. Biochem. 19:567-576, 2008.
  20. C.L. Gentile and M.J. Pagliassotti. The endoplasmic reticulum as a therapeutic target in non-alcoholic fatty liver disease. Curr. Opin. Invest. Drugs 9:1084-1088, 2008.
  21. M.J. Pagliassotti, K.T. Pfaffenbach and T.J. Horton. Techniques used to assess insulin action. In: Insulin Resistance and Metabolic Syndrome: Childhood Precursors and Adult Disease. Kristen Nadeau and Phillip Zeitler, editors. The Humana Press, Inc. 2008.

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